"[N]ew Government, laying its foundation on such principles and organizing its powers in such form, as to them shall seem most likely to effect their Safety and Happiness."

Most likely!

Seems most likely...

That's almost devil-may-care! Are we playing the odds here?

What if some big project today, something much less momentous than an all-new government — let's say Obamacare — were presented on the theory that it seems most likely to make us safe and happy.

You'd scream no, wouldn't you? You'd blog/comment with derision and contempt at the dangerousness of radical change. Wouldn't you?